Dr. Ogochukwu Amaeze
Senior Lecturer
Specialization: Pharmacokinetics And Phamacogenetics
Personal Statement
I am a pharmacist passionate about optimising medication use in special populations using advanced pharmacokinetic, pharmacogenetic, and pharmacometric tools. My research focuses on pharmacokinetic modelling of drug disposition in paediatrics, pregnant and lactating women, as well as the development of physiologically-based pharmacokinetic (PBPK) models to predict complex drug-drug and drug-disease interactions. In addition, I am actively exploring adverse interactions between conventional medicines and African herbal remedies, and using PBPK models to predict clinically relevant herb-drug interactions. I am also investigating the influence of ancestry-specific pharmacogenetics on drug disposition in the Nigerian population. My overarching objective is to translate mechanistic insights from drug pharmacokinetics and population-level pharmacogenetic variations into predictive tools that inform clinical decision-making and optimise therapeutic outcomes.
Education / Training
| institution | degree | completion date | field of study |
|---|---|---|---|
| University of Lagos | B.Pharm. | 09/2009 | Pharmacy |
| University of Lagos | M.Sc. | 04/2014 | Clinical Pharmacy |
| University of Lagos | Ph.D. | 01/2020 | Clinical Pharmacy |
Positions, Scientific Appointments and Honours
- Member – International Society for the Study of Xenobiotics Africa Chapter Sterling Committee (2023 – Present)
- Fulbright Foreign Student Program Award 2017 – 2018
- International Visitors Leadership Program Alumni Association, STEM educator and mentor, leadership and mentoring programs for secondary school students in Lagos state public schools (2019 – 2021).
- Member of editorial board (Nigerian Journal of Pharmaceutical Research)
- Member of editorial board (Drug Metabolism and Disposition)
Selected Most recent Publications/Contributions to knowledge
- Amaeze O, Isoherranen N, and Shum S. (2025). The absorption, distribution, metabolism and elimination characteristics of small interfering RNA therapeutics and the opportunity to predict disposition in pregnant women. Drug Metabolism and Disposition 53(1): 100018.
- Amaeze OU, and Isoherranen N (2023). Application of a physiologically based pharmacokinetic model to predict isoniazid disposition during pregnancy. Clinical and Translational Science 16(11), 2163–2176.
- Amaeze OU, Czuba LC, Yadav AS, Fay EE, LaFrance J, Shum S, Moreni SL, Mao J, Huang W, Isoherranen N, and Hebert MF (2023). Impact of Pregnancy and Vitamin A Supplementation on CYP2D6 Activity. Journal of Clinical Pharmacology 63(3), 363–372.
- Amaeze OU, Marques EM, Wei W, Lazzaro S, Johnson N, Varma M, and Slitt AS (2021). Evaluation of Nigerian Medicinal Plants Extract on Human P-glycoprotein and Cytochrome P450 Enzyme Induction: Implications for Herb-Drug Interaction. Current Drug Metabolism 22, 1103-1113.
- Amaeze O, Eng H, Horlbogen L, Varma MVS, and Slitt AS (2021). Cytochrome P450 Enzyme Inhibition and Herb-Drug Interaction Potential of Medicinal Plant Extracts Used for Management of Diabetes in Nigeria. Eur J Drug Metab Pharmacokinet 46(3):437-450.
Collaborations/ Networks
- Akinyemi Oni-Orisan, University of California, San Francisco, USA.
- Nina Isoherranen, University of Washington, Seattle, Washington, USA.
- Laura Ramsey, Children’s Mercy, Kansas city, Kansas, USA.
- Moshood Akinleye, University of Lagos, Nigeria.
- Ogheneochuko Orherhe, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
