Dr. Ogochukwu Amaeze

I am a pharmacist passionate about optimising medication use in special populations using advanced pharmacokinetic, pharmacogenetic, and pharmacometric tools. My research focuses on pharmacokinetic modelling of drug disposition in paediatrics, pregnant and lactating women, as well as the development of physiologically-based pharmacokinetic (PBPK) models to predict complex drug-drug and drug-disease interactions. In addition, I am actively exploring adverse interactions between conventional medicines and African herbal remedies, and using PBPK models to predict clinically relevant herb-drug interactions. I am also investigating the influence of ancestry-specific pharmacogenetics on drug disposition in the Nigerian population. My overarching objective is to translate mechanistic insights from drug pharmacokinetics and population-level pharmacogenetic variations into predictive tools that inform clinical decision-making and optimise therapeutic outcomes.