Dr. Ogochukwu Amaeze

Selected Recent Publications / Contributions to Knowledge

1. Amaeze O, Isoherranen N, and Shum S. (2025). The absorption, distribution, metabolism and elimination characteristics of small interfering RNA therapeutics and the opportunity to predict disposition in pregnant women. Drug Metabolism and Disposition 53(1): 100018.
2. Amaeze OU, and Isoherranen N (2023). Application of a physiologically based pharmacokinetic model to predict isoniazid disposition during pregnancy. Clinical and Translational Science 16(11), 2163–2176.
3. Amaeze OU, Czuba LC, Yadav AS, Fay EE, LaFrance J, Shum S, Moreni SL, Mao J, Huang W, Isoherranen N, and Hebert MF (2023). Impact of Pregnancy and Vitamin A Supplementation on CYP2D6 Activity. Journal of Clinical Pharmacology 63(3), 363–372.
4. Amaeze OU, Marques EM, Wei W, Lazzaro S, Johnson N, Varma M, and Slitt AS (2021). Evaluation of Nigerian Medicinal Plants Extract on Human P-glycoprotein and Cytochrome P450 Enzyme Induction: Implications for Herb-Drug Interaction. Current Drug Metabolism 22, 1103-1113.
5. Amaeze O, Eng H, Horlbogen L, Varma MVS, and Slitt AS (2021). Cytochrome P450 Enzyme Inhibition and Herb-Drug Interaction Potential of Medicinal Plant Extracts Used for Management of Diabetes in Nigeria. Eur J Drug Metab Pharmacokinet 46(3):437-450.

Collaborations / Networks

• Akinyemi Oni-Orisan, University of California, San Francisco, USA.
• Nina Isoherranen, University of Washington, Seattle, Washington, USA.
• Laura Ramsey, Children’s Mercy, Kansas city, Kansas, USA.
• Moshood Akinleye, University of Lagos, Nigeria.
• Ogheneochuko Orherhe, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.